The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

Interest in the role of peptides in the nervous system was sparked 20 years ago when
Guillemin, Schally, and their colleagues first identified the peptidergic nature of the …

Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and
their receptors in primary sensory neurons are observed. These changes involve the …

The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Abstract Changes in phenotype or connectivity of primary afferent neurons following
peripheral nerve injury may contribute to the hyperalgesia and allodynia associated with …

Ca2+ channels in distinct subcellular compartments of neurons mediate voltage-dependent
Ca2+ influx, which integrates synaptic responses, regulates gene expression, and initiates …