Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at
most a few percent of manipulated embryos resulting in live births. Many of those that …

Introduction 3. The Stepwise Nature of Genome Activation 4. Changes in Histone Content
Accompanying Genome Activation 4.1. Changes in Histone Protein Expression 4.2 …

Background Findings from several studies support the conclusion that spermatozoa contain
a complex repertoire of mRNAs. Even though these mRNAs are thought to provide an …

The female gamete (the oocyte) serves the distinct purpose of transmitting the maternal
genome and other maternal factors that are critical for post-ovulation events 1, 2, 3, 4 …

In recent years increasing numbers of women from wealthy countries have turned to egg
donation, egg freezing, and in vitro fertilization to become pregnant, especially later in life …

Full-term development has now been achieved in several mammalian species by transfer of
somatic nuclei into enucleated oocytes [1, 2]. Although a high proportion of such …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

For many years, researchers cloning mammals experienced little success, but recent
advances have led to the successful cloning of several mammalian species. However …

Epigenetic control of gene expression is a consistent feature of differentiated mammalian
cell types. Epigenetic expression patterns are mitotically heritable and are stably maintained …

The preimplantation bovine embryo is initially under the control of maternal genomic
information that is accumulated during oogenesis. The genetic programme of development …