MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their
metabolic pathways from fatty acid β-oxidation and pyruvate oxidation via the TCA cycle to …

Sustained glucose and glutamine transport are essential for activated T lymphocytes to
support ATP and macromolecule biosynthesis. We found that glutamine and glucose also …

Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …