Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …

Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are
engineered to recognize and kill cancer cells, has achieved striking success in some …

In immunology, the discovery of regulatory T (Treg) cells was a major breakthrough. Treg
cells play a key role in pregnancy maintenance, in the prevention of autoimmune responses …

Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of
AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid …

Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both
immunogenic and tolerogenic immune modulation. Clinical use has been hampered by …

Obesity-related chronic low-grade inflammation may trigger insulin resistance and type 2
diabetes (T2D) development. Cells with regulatory phenotype have been shown to be …

Despite tremendous progress in cancer treatment in recent years, treatment resistance is still
a major challenge for a great number of patients. One of the main causes is regulatory T …

Psoriasis is a chronic inflammatory skin disease, the etiology of which has not been fully
elucidated, in which CD8+ T cells play an important role in the pathogenesis of psoriasis …

Abstract Background The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-
Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival …

Humans can be exposed to endocrine disruptors (EDs) in numerous ways. EDs can interfere
with endogenous hormones at different levels, resulting in numerous adverse human health …