Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

[HTML][HTML] Why does viral RNA sometimes persist after recovery from acute infections?

DE Griffin - PLoS biology, 2022 - journals.plos.org
DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …

Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults

B Ackerson, HF Tseng, LS Sy, Z Solano… - Clinical Infectious …, 2019 - academic.oup.com
Background Respiratory syncytial virus (RSV) is an important cause of serious respiratory
illness in older adults. Comparison of RSV and influenza infection in hospitalized older …

[HTML][HTML] COPD exacerbations: defining their cause and prevention

JA Wedzicha, TAR Seemungal - The lancet, 2007 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma

LG Wood, N Shivappa, BS Berthon… - Clinical & …, 2015 - Wiley Online Library
Background Asthma prevalence has increased in recent years, and evidence suggests that
diet may be a contributing factor. Increased use of processed foods has led to a decrease in …

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

JM Leung, PY Tiew, M Mac Aogáin, KF Budden… - …, 2017 - Wiley Online Library
ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …

Viral and host factors in human respiratory syncytial virus pathogenesis

PL Collins, BS Graham - Journal of virology, 2008 - Am Soc Microbiol
Human respiratory syncytial virus (RSV) was first isolated in 1956 from a laboratory
chimpanzee with upper respiratory tract disease (for general reviews, see references 21, 57 …

The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma

LG Wood, KJ Baines, J Fu, HA Scott, PG Gibson - Chest, 2012 - Elsevier
Background The role of systemic inflammation in asthma is unclear. The aim of this study
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …

Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis

MA Martínez-García, JJ Soler-Cataluña… - Chest, 2007 - Elsevier
Background Bronchiectasis remains a major public health problem, but factors influencing
its natural history are not well characterized. The objective of our study was to explore …