The review introduces the stages of formation and experimental confirmation of the
hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and …

The review discusses the potential relationship between hypoxia resistance and longevity,
the influence of carbon dioxide on the mechanisms of aging of the mammalian organism …

Introduction In the present study, we aimed to test the hypothesis that hypercapnia,
independently and/or in combination with hypoxia, can activate signaling pathways related …

The application of combined hypoxia and hypercapnia (hypercapnic hypoxia) during
respiratory exercises results in a maximum increase in resistance to acute hypoxia and …

Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in
which a number of endogenous molecules are known to be involved. Tuberous sclerosis …

Persistent postoperative pain causes influence the life quality of many patients. The
Epac/PKC pathway has been indicated to regulate mechanical hyperalgesia. The present …

The mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and
its combination with hypoxia are not studied sufficiently. The study aims to test the …

The function of guanine nucleotide exchange protein conversion factor (Epac1) in
regenerating nerves, stimulating insulin release, controlling vascular pressure, and …

Авторами показана максимальная нейропротекторная эффективность сочетанного
воздействия гипоксии и гиперкапнии по сравнению с их изолированным …

We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the
development of ischemic tolerance of the brain after combined and isolated exposure to …