Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1
(mTORC1), which functions both as a nutrient sensor and a master controller of virtually all …

Obesity is one of the foremost risk factors in coronavirus infection resulting in severe illness
and mortality as the pandemic progresses. Obesity is a well-known predisposed chronic …

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …

The prevalence of being overweight and obese has been expanded dramatically in recent
years worldwide. Obesity usually occurs when the energetic introit overtakes energy …

Innate immune defense against deep tissue infection by Staphylococcus aureus is
orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into …

Molecular mechanisms transducing physical forces in the bone microenvironment to
regulate bone mass are poorly understood. Here, we used mouse genetics, mechanical …