Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

The tone of vascular smooth muscle cells is a primary determinant of the total peripheral
vascular resistance and hence the arterial blood pressure. Most forms of hypertension …

The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …

Nitric oxide (NO) inhibits vascular contraction by activating cGMP-dependent protein kinase I-
α (PKGI-α), which causes dephosphorylation of myosin light chain (MLC) and vascular …

Hypertension affects more than 1.5 billion people worldwide but the precise cause of
elevated blood pressure (BP) cannot be determined in most affected individuals …

Rgs2, a regulator of G proteins, lowers blood pressure by decreasing signaling through Gαq.
Human patients expressing Met-Leu-Rgs2 (ML-Rgs2) or Met-Arg-Rgs2 (MR-Rgs2) are …

Here we present a strategy to determine the genetic basis of variance in complex
phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We …