Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to
DNA lesions and catalyzes poly (ADP-ribosyl) ation of nuclear acceptor proteins, including …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

Virus infection modulates both host immunity and host genomic stability. Poly (ADP-ribose)
polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic …

Death ligands not only induce apoptosis but can also trigger necrosis with distinct
biochemical and morphological features. We recently showed that in L929 cells CD95 …

Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D.
Recently, the mitochondrial effects of vitamin D have been characterized in many cell types …

The hallmarks of cancer capture the most essential phenotypic characteristics of malignant
transformation and progression. Although numerous factors involved in this multi-step …

Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …

In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …