[HTML][HTML] The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
[HTML][HTML] PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
GV Chaitanya, JS Alexander, PP Babu - Cell communication and signaling, 2010 - Springer
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
[HTML][HTML] The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis
M Mashimo, M Onishi, A Uno, A Tanimichi… - Journal of Biological …, 2021 - ASBMB
Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to
DNA lesions and catalyzes poly (ADP-ribosyl) ation of nuclear acceptor proteins, including …
DNA lesions and catalyzes poly (ADP-ribosyl) ation of nuclear acceptor proteins, including …
Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: an update
C Soldani, AI Scovassi - Apoptosis, 2002 - Springer
Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …
in many processes, including DNA repair and cell death. The best known poly (ADP …
[HTML][HTML] Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
F Wang, M Zhao, B Chang, Y Zhou, X Wu, M Ma, S Liu… - Molecular Cell, 2022 - cell.com
Virus infection modulates both host immunity and host genomic stability. Poly (ADP-ribose)
polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic …
polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic …
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling
M Los, M Mozoluk, D Ferrari… - Molecular biology of …, 2002 - Am Soc Cell Biol
Death ligands not only induce apoptosis but can also trigger necrosis with distinct
biochemical and morphological features. We recently showed that in L929 cells CD95 …
biochemical and morphological features. We recently showed that in L929 cells CD95 …
[HTML][HTML] Vitamin D receptor is necessary for mitochondrial function and cell health
C Ricca, A Aillon, L Bergandi, D Alotto… - International journal of …, 2018 - mdpi.com
Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D.
Recently, the mitochondrial effects of vitamin D have been characterized in many cell types …
Recently, the mitochondrial effects of vitamin D have been characterized in many cell types …
[HTML][HTML] Guidelines for the selection of functional assays to evaluate the hallmarks of cancer
The hallmarks of cancer capture the most essential phenotypic characteristics of malignant
transformation and progression. Although numerous factors involved in this multi-step …
transformation and progression. Although numerous factors involved in this multi-step …
[HTML][HTML] Functional aspects of PARP1 in DNA repair and transcription
Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
[HTML][HTML] Cell death pathways: a novel therapeutic approach for neuroscientists
In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …