Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …

The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving
potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

Mitochondria are organelles present in almost all eukaryotic cells, where they represent the
main site of energy production. Mitochondria are involved in several important cell …

High copy number, damage prone, and lean on repair mechanisms are unique features of
mitochondrial DNA (mtDNA) that are hard to reconcile with its essentiality for oxidative …

Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …