Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Regulation of pancreatic beta-cell mass
L Bouwens, I Rooman - Physiological reviews, 2005 - journals.physiology.org
Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin… - Nature …, 2014 - nature.com
Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
O Cabrera, DM Berman, NS Kenyon… - Proceedings of the …, 2006 - National Acad Sciences
The cytoarchitecture of human islets has been examined, focusing on cellular associations
that provide the anatomical framework for paracrine interactions. By using confocal …
that provide the anatomical framework for paracrine interactions. By using confocal …
[HTML][HTML] Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
D Jacobs-Tulleneers-Thevissen, M Chintinne, Z Ling… - Diabetologia, 2013 - Springer
Methods Cultured human islet cells were equally distributed over free and alginate-
encapsulated grafts before implantation in, respectively, the kidney capsule and the …
encapsulated grafts before implantation in, respectively, the kidney capsule and the …
A practical guide to rodent islet isolation and assessment
JD Carter, SB Dula, KL Corbin, R Wu… - Biological procedures …, 2009 - Springer
Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood
glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional …
glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional …
Bioengineering the endocrine pancreas: intraomental islet transplantation within a biologic resorbable scaffold
Transplantation of pancreatic islets is a therapeutic option to preserve or restore β-cell
function. Our study was aimed at developing a clinically applicable protocol for extrahepatic …
function. Our study was aimed at developing a clinically applicable protocol for extrahepatic …
Revascularization of transplanted pancreatic islets and role of the transplantation site
Since the initial reporting of the successful reversal of hyperglycemia through the
transplantation of pancreatic islets, significant research efforts have been conducted in …
transplantation of pancreatic islets, significant research efforts have been conducted in …
Biological and biomaterial approaches for improved islet transplantation
AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET
Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines
Transplantation of human islets is an attractive alternative to daily insulin injections for
patients with type 1 diabetes. However, the majority of islet recipients lose graft function …
patients with type 1 diabetes. However, the majority of islet recipients lose graft function …