A comprehensive review on triazole based conjugates as acetylcholinesterase inhibitors: Design strategies, synthesis, biological activity, structure activity …
Significant advancements have been made in development of Acetylcholinesterase
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease
Q Li, S Qi, J Liang, Y Tian, S He, Q Liao, S Xing… - Chemico-Biological …, 2023 - Elsevier
Triazole scaffolds, a series of 5-membered heterocycles, are well known for their high
efficacy, low toxicity, and superior pharmacokinetics. Alzheimer's disease (AD) is the first …
efficacy, low toxicity, and superior pharmacokinetics. Alzheimer's disease (AD) is the first …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
Novel 1, 2, 4‐triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation
E Koçak Aslan, A Sezer… - Archiv der …, 2024 - Wiley Online Library
Butyrylcholinesterase (BChE) is considered a promising therapeutic target for treating
Alzheimer's disease due to the increase in the levels and activity of BChE in the late stage of …
Alzheimer's disease due to the increase in the levels and activity of BChE in the late stage of …
Synthesis of new triazole-based thiosemicarbazone derivatives as anti-Alzheimer's disease candidates: Evidence-based in vitro study
Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized
by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly …
by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly …
Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors
U Kalsoom, M Alazmi, HSUB Farrukh… - ACS Chemical …, 2021 - ACS Publications
Misfolding and fibrillar aggregation of Aβ is a characteristic hallmark of Alzheimer's disease
and primarily participates in neurodegenerative pathologies. There has been no …
and primarily participates in neurodegenerative pathologies. There has been no …
Innovative cholinergic scaffolds, synthesis, and characterization of substituted 1,2,4-triazole-3-ylthio-N-acetamides and their in silico studies: supplement against …
Neurodegeneration is an unfortunate condition associated with the steady loss of structures
and functions of neurons. The most common complication that arises from …
and functions of neurons. The most common complication that arises from …
Synthesis and evaluation of novel 1, 2, 4-substituted triazoles for urease and anti-proliferative activity.
Abstract: 1, 2, 4-triazoles are a major group of heterocyclic compounds. In the current work, a
concise library of such triazoles synthesized through a multistep protocol. The synthesis …
concise library of such triazoles synthesized through a multistep protocol. The synthesis …
Serendipitous N, S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1, 2, 4 …
In the present research work, a serendipitous regioselective synthesis of DNA targeting
agents, 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1, 2, 4-triazoles, has been achieved …
agents, 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1, 2, 4-triazoles, has been achieved …