[HTML][HTML] The target of rapamycin signalling pathway in ageing and lifespan regulation
Ageing is a complex trait controlled by genes and the environment. The highly conserved
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …
[HTML][HTML] Targeted genome editing of plants and plant cells for biomanufacturing
Plants have provided humans with useful products since antiquity, but in the last 30 years
they have also been developed as production platforms for small molecules and …
they have also been developed as production platforms for small molecules and …
Deciphering D4Z4 CpG methylation gradients in fascioscapulohumeral muscular dystrophy using nanopore sequencing
RJ Butterfield, DM Dunn, B Duval, S Moldt… - Genome …, 2023 - genome.cshlp.org
Fascioscapulohumeral muscular dystrophy (FSHD) is caused by a unique genetic
mechanism that relies on contraction and hypomethylation of the D4Z4 macrosatellite array …
mechanism that relies on contraction and hypomethylation of the D4Z4 macrosatellite array …
[HTML][HTML] Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
ME van Breugel, I van Kruijsbergen, C Mittal, C Lieftink… - Molecular Cell, 2023 - cell.com
Transcription of tRNA genes by RNA polymerase III (RNAPIII) is tuned by signaling
cascades. The emerging notion of differential tRNA gene regulation implies the existence of …
cascades. The emerging notion of differential tRNA gene regulation implies the existence of …
[HTML][HTML] The GATA transcription factor Gaf1 represses tRNAs, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1
M Rodríguez-López, S Gonzalez, O Hillson… - Cell Reports, 2020 - cell.com
Summary Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging.
Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1 …
Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1 …
[HTML][HTML] The choreography of chromatin in RNA polymerase III regulation
ME van Breugel, A Gerber… - Biochemical Society …, 2024 - portlandpress.com
Regulation of eukaryotic gene expression involves a dynamic interplay between the core
transcriptional machinery, transcription factors, and chromatin organization and modification …
transcriptional machinery, transcription factors, and chromatin organization and modification …
[HTML][HTML] PltRNAdb: Plant transfer RNA database
MM Mokhtar, A El Allali - PLoS One, 2022 - journals.plos.org
Transfer RNAs (tRNAs) are intermediate-sized non-coding RNAs found in all organisms that
help translate messenger RNA into protein. Recently, the number of sequenced plant …
help translate messenger RNA into protein. Recently, the number of sequenced plant …
Interchangeable parts: the evolutionarily dynamic tRNA population in plant mitochondria
Transfer RNAs (tRNAs) remain one of the very few classes of genes still encoded in the
mitochondrial genome. These key components of the protein translation system must …
mitochondrial genome. These key components of the protein translation system must …
Combining tRNA sequencing methods to characterize plant tRNA expression and post-transcriptional modification
Differences in tRNA expression have been implicated in a remarkable number of biological
processes. There is growing evidence that tRNA genes can play dramatically different roles …
processes. There is growing evidence that tRNA genes can play dramatically different roles …
Predicting transfer RNA gene activity from sequence and genome context
BP Thornlow, J Armstrong, AD Holmes… - Genome …, 2020 - genome.cshlp.org
Transfer RNA (tRNA) genes are among the most highly transcribed genes in the genome
owing to their central role in protein synthesis. However, there is evidence for a broad range …
owing to their central role in protein synthesis. However, there is evidence for a broad range …