Hand-foot-and-mouth disease-associated enterovirus and the development of multivalent HFMD vaccines

X Zhang, Y Zhang, H Li, L Liu - International Journal of Molecular …, 2022 - mdpi.com
Hand-foot-and-mouth disease (HFMD) is an infectious disease of children caused by more
than 20 types of enteroviruses, with most cases recovering spontaneously within …

Enteroviruses: epidemic potential, challenges and opportunities with vaccines

M Jartti, M Flodström-Tullberg… - Journal of Biomedical …, 2024 - Springer
Enteroviruses (EVs) are the most prevalent viruses in humans. EVs can cause a range of
acute symptoms, from mild common colds to severe systemic infections such as meningitis …

Recent advances in enterovirus A71 infection and antiviral agents

Y Wei, H Liu, D Hu, Q He, C Yao, H Li, K Hu… - Laboratory …, 2023 - Elsevier
Abstract Enterovirus A71 (EV-A71) is one of the major causative agents of hand-foot-and-
mouth disease (HFMD) that majorly affects children. Most of the time, HFMD is a mild …

Understanding neurotropic enteric viruses: routes of infection and mechanisms of attenuation

V Lulla, A Sridhar - Cellular and Molecular Life Sciences, 2024 - Springer
The intricate connection between the gut and the brain involves multiple routes. Several viral
families begin their infection cycle in the intestinal tract. However, amongst the long list of …

ERK inhibition aids IFN-β promoter activation during EV71 infection by blocking CRYAB degradation in SH-SY5Y cells

D Chen, C Chen, J Tan, J Yang… - Pathogens and …, 2023 - academic.oup.com
Abstract Enterovirus 71 (EV71) can cause severe hand-foot-and-mouth disease with
neurological complications. It has evolved multiple mechanisms to compromise the host type …

Neutralization of African enterovirus A71 genogroups by antibodies to canonical genogroups

R Volle, L Luo… - Journal of General …, 2023 - microbiologyresearch.org
Enterovirus 71 (EV-A71) is a major public health problem, causing a range of illnesses from
hand-foot-and-mouth disease to severe neurological manifestations. EV-A71 strains have …

[HTML][HTML] Antiviral drugs (synthetic small molecule inhibitors and nature drugs) against EV71 in enteroviruses: advances and perspectives

Y Liu, Y Xi, L Ji, Q Shen, W Zhang, M Xue - … Complementary Medicine and …, 2023 - Elsevier
Abstract Background Enterovirus 71 (EV71) is a major virus that causes hand-foot-mouth
disease. In cases of infants and young children, EV71 infection has been associated with …

A multiplex one-step fluorescence quantitative differential diagnosis method for severe hand, foot and mouth disease caused by coxsackievirus A16

R Jia, J Yin, W Cheng, S Yuan, L Li, X Song… - Journal of Virological …, 2024 - Elsevier
Hand foot and mouth disease (HFMD) is a common childhood infectious disease which is
caused by human enterovirus. The objective of this study was to develop a rapid, sensitive …

[HTML][HTML] Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening

QY Zhang, JQ Li, Q Li, Y Zhang, ZR Zhang, XD Li… - Virologica Sinica, 2024 - Elsevier
Hand, foot, and mouth disease (HFMD) is a common pediatric illness mainly caused by
enteroviruses, which are important human pathogens. Currently, there are no available …

Effectiveness of Enterovirus 71 inactivated vaccines against hand, foot, and mouth disease: A test-negative case-control study

Y Zhang, J Cui, F Liu, Y Song, Q Wang… - Human Vaccines & …, 2024 - Taylor & Francis
ABSTRACT The Enterovirus A71 (EV-A71) vaccine was introduced in China in December
2015 as a preventive measure against hand, foot, and mouth disease (HFMD) caused by EV …