Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation, but also dormancy and cellular …

Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in
tumorigenesis. They were initially recognized to promote tumor progression by remodeling …

The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …

For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been
recognized as a key component in cancer progression. Initially, the primary roles assigned …

Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue
homeostasis, and this process is altered during skin cancer progression. In melanoma …

Changing the characteristics of cells from epithelial states to mesenchymal properties is a
key process involved in developmental and physiological processes as well as in many …

Proper processing of collagens COL1 and COL6 is required for normal function of adipose
tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation …

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal
deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a …

Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by
cancer stem cells (CSC). The chemokine CXC motif ligand-1 (CXCL1) is involved in BC …

The pathogenesis of gallbladder cancer is complex, involving environmental and genetic
risk factors. The matrix metallopeptidase 14 (MMP14) alters the tumor microenvironment and …