Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …

The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …

Alzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal
diagnosis of dementia. AD biomarker models provide a framework for precision medicine …

Topics discussed at the “Leveraging Existing Data and Analytic Methods for Health
Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias” …

Four decades ago in 1985, alleles of apolipoprotein E (ApoE) ε2/ε3/ε4 became famous for
explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark …

Background: The global race-dependent association of Alzheimer's disease (AD) and
apolipoprotein E (APOE) genotype is not well understood. Transethnic analysis of APOE …

Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the
examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity …

Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be
associated with complex haplotypes or compound genotypes. Methods We examined …

Little is known of gene–environment interactions for Alzheimer's disease (AD) risk factors.
Apolipoprotein E (APOE) and neighbors on chromosome 19q13. 3 have variants associated …

Abstract INTRODUCTION Apolipoprotein E (APOE) ε4‐carrier status or ε4 allele count are
included in analyses to account for the APOE genetic effect on Alzheimer's disease (AD); …