Spermatogenesis in humans and its affecting factors

FTL Neto, PV Bach, BB Najari, PS Li… - Seminars in cell & …, 2016 - Elsevier
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

[HTML][HTML] Molecular mechanisms beyond glucose transport in diabetes-related male infertility

MG Alves, AD Martins, L Rato, PI Moreira… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

MG Alves, L Rato, RA Carvalho, PI Moreira… - Cellular and molecular …, 2013 - Springer
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

High‐energy diets: a threat for male fertility?

L Rato, MG Alves, JE Cavaco, PF Oliveira - Obesity Reviews, 2014 - Wiley Online Library
Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …

The Warburg effect revisited—lesson from the Sertoli cell

PF Oliveira, AD Martins, AC Moreira… - Medicinal research …, 2015 - Wiley Online Library
Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

High‐energy diets may induce a pre‐diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

L Rato, MG Alves, TR Dias, G Lopes, JE Cavaco… - …, 2013 - Wiley Online Library
Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …

Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function

MG Alves, AD Martins, JE Cavaco, S Socorro… - Tissue …, 2013 - Taylor & Francis
Blood testis barrier (BTB) is one of the tightest blood-barriers controlling the entry of
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …

Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1

AD Martins, MP Monteiro, BM Silva, A Barros… - Toxicology and Applied …, 2019 - Elsevier
Obesity incidence has pandemic proportions and is expected to increase even further.
Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological …

The molecular mechanism of sex hormones on Sertoli cell development and proliferation

W Shah, R Khan, B Shah, A Khan, S Dil… - Frontiers in …, 2021 - frontiersin.org
Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Sperm glucose transport and metabolism in diabetic individuals

TR Dias, MG Alves, BM Silva, PF Oliveira - Molecular and Cellular …, 2014 - Elsevier
Individuals with diabetes mellitus (DM) present marked reduction in sperm quality and
higher DNA damage in spermatozoa, evidencing that this metabolic disorder impairs male …