Spermatogenesis in humans and its affecting factors
FTL Neto, PV Bach, BB Najari, PS Li… - Seminars in cell & …, 2016 - Elsevier
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …
into spermatozoa requires the participation of several cell types, hormones, paracrine …
[HTML][HTML] Molecular mechanisms beyond glucose transport in diabetes-related male infertility
Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …
Although during a few years it was suggested that DM had no significant effect in male …
Hormonal control of Sertoli cell metabolism regulates spermatogenesis
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …
reach far beyond the physical support of germ cells, as they are responsible for creating the …
High‐energy diets: a threat for male fertility?
Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …
The Warburg effect revisited—lesson from the Sertoli cell
PF Oliveira, AD Martins, AC Moreira… - Medicinal research …, 2015 - Wiley Online Library
Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …
High‐energy diets may induce a pre‐diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters
Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …
epidemic proportions. Young male diabetic patients present high infertility/subfertility …
Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function
Blood testis barrier (BTB) is one of the tightest blood-barriers controlling the entry of
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …
Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1
Obesity incidence has pandemic proportions and is expected to increase even further.
Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological …
Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological …
The molecular mechanism of sex hormones on Sertoli cell development and proliferation
Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …
Sperm glucose transport and metabolism in diabetic individuals
Individuals with diabetes mellitus (DM) present marked reduction in sperm quality and
higher DNA damage in spermatozoa, evidencing that this metabolic disorder impairs male …
higher DNA damage in spermatozoa, evidencing that this metabolic disorder impairs male …