Chromosome segregation—the partitioning of genetic material into two daughter cells—is
one of the most crucial processes in cell division. In all Eukaryotes, chromosome …

Cellular nuclei are bound by two uniformly separated lipid membranes that are fused with
each other at numerous donut-shaped pores. These membranes are structurally supported …

The nuclear pore complex (NPC) is an eightfold symmetrical channel providing selective
transport of biomolecules across the nuclear envelope. Each NPC consists of∼ 30 different …

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward
pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein …

Mitosis is the process of one cell dividing into two daughters, such that each inherits a single
and complete copy of the genome of their mother. This is achieved through the equal …

Eukaryotes segregate chromosomes in" open" or" closed" mitosis, depending on whether
their nuclear envelopes (NEs) break down or remain intact. Here we show that the control of …

In animal cells the nuclear lamina, which consists of lamins and lamin-associated proteins,
serves several functions: it provides a structural scaffold for the nuclear envelope and tethers …

Eukaryotes remodel the nucleus during mitosis using a variety of mechanisms that differ in
the timing and the extent of nuclear envelope (NE) breakdown. Here, we probe the …

Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary
Gergely, Eileen O'Toole, Ammon Crapo, Loren Hough, Richard McIntosh, Matthew Glaser …

The essential functions required for mitotic spindle assembly and chromosome biorientation
and segregation are not fully understood, despite extensive study. To illuminate the …