Neurons are metabolically handicapped in the sense that they are not able to perform de
novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid (GABA) from glucose …

Abstract Leif Hertz, MD, D. Sc.(honōris causā)(1930–2018), was one of the original and
noteworthy participants in the International Conference on Brain Energy Metabolism …

The brain is a steroidogenic organ that expresses steroidogenic enzymes and produces
neurosteroids. Although considerable information is now available regarding the …

The anticonvulsant topiramate is effective in laboratory animals against maximal
electroshock seizures, amygdala kindling, and spike-wave discharges and has …

The nature of the toxic form of amyloid-beta peptide (Aβ) involved in early Alzheimer's
disease (AD) pathology and whether it is the fibrillar or the oligomeric peptide that is the …

Purpose: These studies further investigate the ability of topiramate (TPM) to enhance γ‐
aminobutyric acid (GABA)‐mediated inhibition through a benzodiazepine‐insensitive …

In this study, we analyzed whether ER Ca2+ release, induced by amyloid-β (Aβ) and prion
(PrP) peptides activates the mitochondrial-mediated apoptotic pathway. In cortical neurons …

Primary cultures of cerebral cortical astrocytes and neurons, as well as neurons growing on
top of the astrocytes (sandwich co-cultures), were incubated with 1-[13 C] glucose or 2-[13 …

Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in
Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca2+ …

The glutamate transporters in the plasma membranes of neural cells secure termination of
the glutamatergic synaptic transmission and keep the glutamate levels below toxic …