Protein tyrosine phosphatases in hypothalamic insulin and leptin signaling
The hypothalamus is critical to the coordination of energy balance and glucose
homeostasis. It responds to peripheral factors, such as insulin and leptin, that convey to the …
homeostasis. It responds to peripheral factors, such as insulin and leptin, that convey to the …
Innate memory T cells
Memory T cells are usually considered to be a feature of a successful immune response
against a foreign antigen, and such cells can mediate potent immunity. However, in mice …
against a foreign antigen, and such cells can mediate potent immunity. However, in mice …
PTP1B is an intracellular checkpoint that limits T-cell and CAR T-cell antitumor immunity
Immunotherapies aimed at alleviating the inhibitory constraints on T cells have
revolutionized cancer management. To date, these have focused on the blockade of cell …
revolutionized cancer management. To date, these have focused on the blockade of cell …
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …
Small molecule degraders of protein tyrosine phosphatase 1B and T‐cell protein tyrosine phosphatase for cancer immunotherapy
Protein tyrosine phosphatase 1B (PTP1B) and T‐cell protein tyrosine phosphatase (TC‐
PTP) play non‐redundant negative regulatory roles in T‐cell activation, tumor antigen …
PTP) play non‐redundant negative regulatory roles in T‐cell activation, tumor antigen …
PTPN 2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
Although adoptive T‐cell therapy has shown remarkable clinical efficacy in haematological
malignancies, its success in combating solid tumours has been limited. Here, we report that …
malignancies, its success in combating solid tumours has been limited. Here, we report that …
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals
RJ Salmond, RJ Brownlie, VL Morrison… - Nature …, 2014 - nature.com
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign
antigens to provide protection against infection. We found that in both naive T cells and …
antigens to provide protection against infection. We found that in both naive T cells and …
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines
Y Ji, C Wrzesinski, Z Yu, J Hu… - Proceedings of the …, 2015 - National Acad Sciences
Lymphodepleting regimens are used before adoptive immunotherapy to augment the
antitumor efficacy of transferred T cells by removing endogenous homeostatic “cytokine …
antitumor efficacy of transferred T cells by removing endogenous homeostatic “cytokine …
Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma
Anaplastic large cell lymphomas (ALCLs) frequently carry oncogenic fusions involving the
anaplastic lymphoma kinase (ALK) gene. Targeting ALK using tyrosine kinase inhibitors …
anaplastic lymphoma kinase (ALK) gene. Targeting ALK using tyrosine kinase inhibitors …
PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis
MR Spalinger, S Kasper, C Chassard, T Raselli… - Mucosal …, 2015 - nature.com
Loss-of-function variants within the gene locus encoding protein tyrosine phosphatase non-
receptor type 2 (PTPN2) are associated with increased risk for Crohn's disease (CD). A …
receptor type 2 (PTPN2) are associated with increased risk for Crohn's disease (CD). A …