[HTML][HTML] Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19

S De Flora, R Balansky, S La Maestra - The FASEB journal, 2020 - ncbi.nlm.nih.gov
COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …

[HTML][HTML] Cellular and molecular signatures of oxidative stress in bronchial epithelial cell models injured by cigarette smoke extract

C Cipollina, A Bruno, S Fasola, M Cristaldi… - International Journal of …, 2022 - mdpi.com
Exposure of the airways epithelium to environmental insults, including cigarette smoke,
results in increased oxidative stress due to unbalance between oxidants and antioxidants in …

Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells

A Sampilvanjil, T Karasawa… - American Journal …, 2020 - journals.physiology.org
Cigarette smoking is a major risk factor for aortic aneurysm and dissection; however, no
causative link between smoking and these aortic disorders has been proven. In the present …

[HTML][HTML] Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in …

KR Paudel, N Panth, B Manandhar, SK Singh, G Gupta… - Antioxidants, 2022 - mdpi.com
Cigarette smoke is considered a primary risk factor for chronic obstructive pulmonary
disease. Numerous toxicants present in cigarette smoke are known to induce oxidative …

[HTML][HTML] Antioxidants and COVID-19

S DE FLORA, R Balansky… - Journal of preventive …, 2021 - ncbi.nlm.nih.gov
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in
infectious diseases, among which viral respiratory diseases. Antioxidants have the capability …

Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations

ET Roxlau, O Pak, S Hadzic… - European …, 2023 - Eur Respiratory Soc
Background Electronic cigarette (e-cigarette) vapour is gaining popularity as an alternative
to tobacco smoking and can induce acute lung injury. However, the specific role of nicotine …

[HTML][HTML] Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro

KR Paudel, DD Clarence, N Panth… - Naunyn-schmiedeberg's …, 2024 - Springer
The purpose of this study was to evaluate the potential of zerumbone-loaded liquid
crystalline nanoparticles (ZER-LCNs) in the protection of broncho-epithelial cells and …

[HTML][HTML] The link between type 2 diabetes mellitus and the polymorphisms of glutathione-metabolizing genes suggests a new hypothesis explaining disease initiation …

I Azarova, E Klyosova, A Polonikov - Life, 2021 - mdpi.com
The present study investigated whether type 2 diabetes (T2D) is associated with
polymorphisms of genes encoding glutathione-metabolizing enzymes such as glutathione …

[HTML][HTML] The impact of genetic polymorphisms in glutamate-cysteine ligase, a key enzyme of glutathione biosynthesis, on ischemic stroke risk and brain infarct size

A Polonikov, I Bocharova, I Azarova, E Klyosova… - Life, 2022 - mdpi.com
The purpose of this pilot study was to explore whether polymorphisms in genes encoding
the catalytic (GCLC) and modifier (GCLM) subunits of glutamate-cysteine ligase, a rate …

[HTML][HTML] Clinical efficacy of carbocysteine in COPD: beyond the mucolytic action

E Pace, I Cerveri, D Lacedonia, G Paone… - Pharmaceutics, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a versatile
and complicated profile, being the fourth most common single cause of death worldwide …