Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to
generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently …

Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) is a critical transcription factor that
regulates the expression of over 1000 genes in the cell under normal and stressed …

Heart disease is the leading cause of death worldwide. A key pathogenic factor in the
development of lethal heart failure is loss of terminally differentiated cardiomyocytes …

Doxorubicin (Dox), a chemotherapeutic agent frequently used to treat cancer, elicits
cardiotoxicity, a condition referred to as Dox-induced cardiotoxicity (DIC), and ferroptosis …

Heme is an essential molecule for living aerobic organisms and is involved in a remarkable
array of diverse biological processes. In the cardiovascular system, heme plays a major role …

Growth and remodeling in the heart is driven by a combination of mechanical and hormonal
signals that produce different patterns of growth in response to exercise, pregnancy, and …

Emerging evidence suggests that microRNAs (miRs) influence skeletal structure by
modulating osteoclastogenesis and bone resorption. We have demonstrated previously that …

Skeletal muscle atrophy is a common muscle disease that is directly caused by an
imbalance in protein synthesis and degradation. At the histological level, it is mainly …

Aim: Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy that
results in death from right ventricular failure (RVF). There is limited understanding of the …

Drug repurposing has gained significant interest in recent years due to the high costs
associated with de novo drug development; however, comprehensive pharmacological …