Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct
formation of immature bone or osteoid tissue by the tumour cells. The classic osteosarcoma …

Background Radiation‐induced sarcoma of the head and neck (RISHN) is a long‐term
complication of treatment. The rarity of this tumour is reflected in the very few series reported …

Background: Children diagnosed with retinoblastoma, a rare cancer of the eye, tend to
develop and die of second primary cancers in childhood and adolescence, but few …

In a series of 882 retinoblastoma patients, 384 known to have the genetic form of the
disease and 498 others, 30 patients developed second primary neoplasms. The spectrum of …

Survivors of the heritable form of retinoblastoma subsequently develop second primary
osteosarcomas at substantially greater frequency than either the general population or …

Sixty‐six patients with well‐documented osteogenic sarcomas arising in bones and soft
tissues after exposure to x‐rays, which represent approximately 5.5 percent of all osteogenic …

A review of 693 patients with bilateral retinoblastoma and 18 patients with
unilateral/germinal retinoblastoma was carried out to find the incidence, time, course and …

Abstract Between 1954 and 1983, 7620 patients were treated for breast carcinoma at Institut
Gustave Roussy (France). Of these patients, 6919 were followed for at least 1 year. Out of …

Retinoblastoma is the most common primary cancer of the eye in children. 1 Although it
represents only approximately 4% of childhood cancer and less than 1% of all human …

The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their
ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that …