Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
Predicting protein–protein interactions from the molecular to the proteome level
Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …
Uncovering disease-disease relationships through the incomplete interactome
INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …
single gene, but rather reflects the interplay of multiple molecular processes. The …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Methods for biological data integration: perspectives and challenges
V Gligorijević, N Pržulj - Journal of the Royal Society …, 2015 - royalsocietypublishing.org
Rapid technological advances have led to the production of different types of biological data
and enabled construction of complex networks with various types of interactions between …
and enabled construction of complex networks with various types of interactions between …
Fundamentals of protein interaction network mapping
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …
one of the major challenges in modern biomedicine. Such information is crucial to …
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
Background The process of generating raw genome sequence data continues to become
cheaper, faster, and more accurate. However, assembly of such data into high-quality …
cheaper, faster, and more accurate. However, assembly of such data into high-quality …
The discovery of integrated gene networks for autism and related disorders
Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there
is compelling evidence that many disease genes will map to a much smaller number of …
is compelling evidence that many disease genes will map to a much smaller number of …
Network target for screening synergistic drug combinations with application to traditional Chinese medicine
S Li, B Zhang, N Zhang - BMC systems biology, 2011 - Springer
Background Multicomponent therapeutics offer bright prospects for the control of complex
diseases in a synergistic manner. However, finding ways to screen the synergistic …
diseases in a synergistic manner. However, finding ways to screen the synergistic …
Machine learning on protein–protein interaction prediction: models, challenges and trends
Protein–protein interactions (PPIs) carry out the cellular processes of all living organisms.
Experimental methods for PPI detection suffer from high cost and false-positive rate, hence …
Experimental methods for PPI detection suffer from high cost and false-positive rate, hence …