Highlights•Viruses predispose to secondary bacterial infection throughout the respiratory
tract.•Viral damage to airway epithelium and aberrant inflammatory responses play key …

Background In children, necrotizing pneumonia (NP) is an uncommon, severe complication
of pneumonia. It is characterized by destruction of the underlying lung parenchyma resulting …

Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis
of persistent wheezing disease in children. In this study, the occurrence of acute respiratory …

Background Viral infections of the respiratory tract represent a major global health concern.
Co-infection with bacteria may contribute to severe disease and increased mortality in …

Abstract Purpose of Review This investigation aims to understand the role and burden of
viral co-infections for acute respiratory illnesses in children. Co-infection can be either viral …

In the pediatric population, respiratory infections are the most common cause of physician
visits. Although many respiratory illnesses are self-limiting viral infections that resolve with …

Fungal infections remain hardly treatable because of unstandardized diagnostic tests,
limited antifungal armamentarium, and more specifically, potential toxic interactions between …

Viruses account for more episodes of respiratory tract disease than any other microbial
pathogens, and exact a significant toll on society and healthcare systems, leading to …

Acute respiratory infections are amongst the leading causes of childhood morbidity and
mortality globally. Viruses are the predominant cause of such infections, but mixed etiologies …

Background. Influenza A virus (IAV) has had the highest morbidity globally over the past
decade. A growing number of studies indicate that the upper respiratory tract (URT) …