This context deals with the design and synthesis of a new set of derivatives containing
thiazole, thiophene, and thieno [2, 3-d] pyrimidine motifs 3-13 starting with 2-((2 …

Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-
acetylnaphthalene and was used as a new key building block for constructing the title …

A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …

It is well-known that thiazole derivatives are usually found in lead structures, which
demonstrate a wide range of pharmacological effects. The aim of this research was to …

Abstract The parent 2-(4-benzyl-1-oxophthalazin-2 (1 H)-yl)-acetohydrazide (4) has twenty-
nine compounds. The starting material for their corresponding mono, dipeptides and …

Background: Some heterocycles having bisamide linkage are receiving much interest due to
their remarkable biological potencies and they are naturally occurring. Some bisamides and …

The target mono-and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …

Heterocycles are important structural components in pharmacophores that are currently
being used to treat several diseases. Among the various heterocyclic scaffolds, nitrogen and …

A simple and efficient synthetic approach to 2-amino-9H-chromeno [2, 3-d] thiazol-9-ones
via copper-promoted cascade reactions was developed. The reaction employed easily …

Despite the crucial role of CDK2 in tumorigenesis, few inhibitors reached clinical trials for
managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial …