Ethnopharmacological relevance The prevalence of diabetes is on a steady increase
worldwide and it is now identified as one of the main threats to human health in the 21st …

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

This review highlights the chemical and biological aspects of natural products containing an
oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in …

In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the
upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with …

AIMS OF THE STUDY: More than 100 cases of nephropathy over the last 10 years caused
by the systemic and longer term application of Chinese snakeroot (Aristolochia fangchi) …

Herbal products are used globally for their perceived health benefits, and as a complement
to alternative therapy to Western medicines. Herbal products can be beneficial, although …

Benzylisoquinoline alkaloids (BIAs) consist of more than 2500 diverse structures largely
restricted to the order Ranunculales and the eumagnoliids. However, BIAs also occur in the …

Background Cancer is the most common cause of death and is still a serious public health
problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially …

Covering: 1960 to 2013 Aristolochic acids are known for causing aristolochic acid
nephropathy, a renal fibrosis often associated with urothelial carcinoma. Aristolochic acid I …

Covering: up to the end of 2010 Naturally-occurring nitro compounds display great structural
diversity, and a wide range of biological activities. This review summarizes current …