The development of animal models of dengue virus (DENV) infection and disease has been
challenging, as epidemic DENV does not naturally infect non-human species. Non-human …

IgG4 autoimmune diseases are characterized by the presence of antigen-specific
autoantibodies of the IgG4 subclass and contain well-characterized diseases such as …

Thrombotic microangiopathies encompass a group of disorders characterized by
microangiopathic hemolytic anemia, thrombocytopenia associated with hyaline thrombi …

Background Thrombocytopenia, bleeding and plasma leakage are cardinal features of
severe dengue. Endothelial cell activation with exocytosis of Weibel-Palade bodies (WPBs) …

Dengue virus (DV) is the most widespread arbovirus, being endemic in over 100 countries,
and is estimated to cause 50 million infections annually. Viral factors, such as the genetic …

For a disease with< 80 years of history, clinical and basic research into thrombotic
thrombocytopenic purpura (TTP) has been significantly accelerated since the identification …

Introduction: Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy
caused by decreased activity of ADAMTS13, resulting in reduced clearance of ultralarge von …

Dengue fever and chikungunya are viral diseases that have spread rapidly throughout the
world in recent decades. The occurrence of complications is well known, including prerenal …

We report a case of thrombotic thrombocytopenic purpura (TTP) that immediately followed
symptomatic dengue virus infection in a pregnant lady. The patient developed dengue fever …

Von Willebrand factor cleaving protease was first identified in 1987 and was further
classified several years later as ADAMTS-13 (a disintegrin and metalloproteinase with …