The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …

Efflux pumps represent an important and large group of transporter proteins found in all
organisms. The importance of efflux pumps resides in their ability to extrude a wide range of …

Globally, tuberculosis (TB) has reemerged as a major cause of morbidity and mortality,
despite the use of the Mycobacterium bovis BCG vaccine and intensive attempts to improve …

A major constraint for developing new anti-tuberculosis drugs is the limited number of
validated targets that allow eradication of persistent infections. Here, we uncover a …

Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a
global health emergency due to an alarming rise of antimicrobial resistance to its treatment …

Mycobacterium tuberculosis Clp proteases are targeted by several antitubercular
compounds, including cyclomarin A (CymA). CymA exerts its toxicity by binding to AAA+ …

Insight into drug transport mechanisms is highly relevant to the efficacious treatment of
tuberculosis (TB). Major problems in TB treatment are related to the transport of …

Thirty years ago Stanley Falkow formulated molecular Koch's postulates as a framework to
help dissect the contribution of microbial genes to their pathogenicity (Box 1). Three years …

Upon nutrient starvation, Chlamydia trachomatis serovar L2 (CTL) shifts from its normal
growth to a non-replicating form, termed persistence. It is unclear if persistence reflects an …

Mycobacteria adapt to infection stresses by entering a reversible non-replicating persistence
(NRP) with slow or no cell growth and broad antimicrobial tolerance. Hypoxia and nutrient …