Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …

Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …

Tau is a microtubule-associated protein that is expressed in neurons. However, in a group of
neurodegenerative diseases named tauopathies–characterized by an increase in …

With Alzheimer's disease (AD) exhibiting reduced ability of neural stem cell renewal, we
hypothesized that de novo mutations controlling embryonic development, in the form of brain …

Tauopathies are neurodegenerative diseases which course with the accumulation of Tau,
mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

Tauopathies are a broad set of neurodegenerative dementias characterized by the
aggregation of Tau protein. Activated microglia and elevated levels of pro-inflammatory …

Tau protein plays a pivotal role in the central nervous system (CNS), participating in
microtubule stability, axonal transport, and synaptic communication. Research interest has …

Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and
regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has …

Alzheimer's disease (AD) and other tauopathies are histopathologically characterized by tau
aggregation, along with a chronic inflammatory response driven by microglia. Over the past …