Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

Pulmonary hypertension (PH) is clinically divided into 5 major types, characterized by
elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) …

Pulmonary hypertension (PH) is a frequent complication of interstitial lung disease (ILD).
Although PH has mostly been described in idiopathic pulmonary fibrosis, it can manifest in …

Pulmonary arterial hypertension (PAH) is a rare disease characterized by high blood
pressure in the pulmonary circulation driven by pathological remodeling of distal pulmonary …

The development of PH in lung disease significantly worsens the morbidity and mortality of
patients with COPD and ILD. However, recent findings show importance of recognizing …

Background Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic
pulmonary fibrosis (IPF). Senescence and insufficient mitophagy in fibroblasts contribute to …

Pulmonary hypertension is one of the difficult situations to treat. Complex pathophysiology,
association of the multiple comorbidities make clinical scenario challenging. Recently it is …

Endothelial dysfunction plays a key role in the initiation and progression of pulmonary
hypertension (PH), a fatal and currently incurable disease associated with increased …

Pulmonary fibrosis (PF) is a progressive chronic lung disease characterized by excessive
deposition of extracellular matrix (ECM) and structural destruction, associated with a severe …

Background Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes
such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of …