Resistance-proof antimicrobial drug discovery to combat global antimicrobial resistance threat

A Upadhayay, J Ling, D Pal, Y Xie, FF Ping… - Drug Resistance …, 2023 - Elsevier
Drug resistance is well-defined as a serious problem in our living world. To survive,
microbes develop defense strategies against antimicrobial drugs. Drugs exhibit less or no …

Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae

B Mlynarczyk-Bonikowska, C Kowalewski… - International Journal of …, 2022 - mdpi.com
The paper presents various issues related to the increasing drug resistance of Neisseria
gonorrhoeae and the occurrence and spread of multidrug-resistant clones. One of the most …

Zoliflodacin: An Oral Spiropyrimidinetrione Antibiotic for the Treatment of Neisseria gonorrheae, Including Multi-Drug-Resistant Isolates

PA Bradford, AA Miller, J O'Donnell… - ACS infectious …, 2020 - ACS Publications
The Centers for Disease Control and the World Health Organization have issued a list of
priority pathogens for which there are dwindling therapeutic options, including antibiotic …

High percentage of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone among isolates from a single hospital in Hangzhou, China

J Yan, Y Chen, F Yang, X Ling, S Jiang… - Journal of …, 2021 - academic.oup.com
Objectives Ceftriaxone is currently the last-remaining empirical antimicrobial therapy for
treatment of gonorrhoea. However, the high-level ceftriaxone-resistant gonococcal FC428 …

Markedly increasing antibiotic resistance and dual treatment of Neisseria gonorrhoeae isolates in Guangdong, China, from 2013 to 2020

X Lin, X Qin, X Wu, Y Liao, Y Yu, Q Xie… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The emergence of multidrug resistance in Neisseria gonorrhoeae is concerning, especially
the cooccurrence of azithromycin resistance and decreased susceptibility to extended …

Global transmission of the penA allele 60.001–containing high-level ceftriaxone-resistant gonococcal FC428 clone and antimicrobial therapy of associated cases: a …

S van der Veen - Infectious Microbes & Diseases, 2023 - journals.lww.com
Neisseria gonorrhoeae is a multidrug-resistant bacterial pathogen for which ceftriaxone is
the only remaining recommended first-line therapy. However, ceftriaxone susceptibility has …

[HTML][HTML] Antibiotic resistance and treatment options for multidrug-resistant gonorrhea

F Yang, J Yan - Infectious Microbes & Diseases, 2020 - journals.lww.com
Gonorrhea is a sexually transmitted disease with a high global incidence. Its causative
agent, Neisseria gonorrhoeae, has shown a remarkable flexibility to adapt and become …

Emergence and Characterization of a Ceftriaxone-Resistant Neisseria gonorrhoeae FC428 Clone Evolving Moderate-Level Resistance to Azithromycin in Shenzhen …

L Zhang, C Zhang, Y Zeng, Y Li, S Huang… - Infection and Drug …, 2021 - Taylor & Francis
We here described a ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone (YL201) with
moderate-level resistance to azithromycin in Shenzhen, South China in 2020. The NG-STAR …

Multiplex PCR and Nanopore Sequencing of Genes Associated with Antimicrobial Resistance in Neisseria gonorrhoeae Directly from Clinical Samples

C Zhang, L Xiu, Y Li, L Sun, Y Li, Y Zeng… - Clinical …, 2021 - academic.oup.com
Background Antimicrobial resistance (AMR) of Neisseria gonorrhoeae has spread
worldwide. Rapid and comprehensive methods are needed to describe N. gonorrhoeae …

Whole-genome sequence analysis of high-level penicillin-resistant strains and antimicrobial susceptibility of Neisseria gonorrhoeae clinical isolates from Thailand

N Nokchan, T Wongsurawat, P Jenjaroenpun… - PLoS …, 2022 - journals.plos.org
Background The increasing rate of antimicrobial-resistant Neisseria gonorrhoeae poses a
considerable public health threat due to the difficulty in treating gonococcal infections. This …