Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease …

Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

Colon cancer is a common preventable cancer. With the adoption of widespread colon
cancer screening in the developed countries, the incidence and mortality of colon cancer …

The risk of colorectal cancer (CRC) is higher in patients with inflammatory bowel disease
(IBD). Population-based data from patients with ulcerative colitis (UC) estimate that the risk …

Abstract Purpose of Review Colorectal cancer (CRC) is the fourth most common cancer in
both men and women in the USA, resulting in over 55,000 deaths annually. Environmental …

Abstract The T helper 17 (Th17) cells in tumor microenvironment play an important role in
colorectal cancer (CRC) progression. This study investigated the mechanism of Th17 cell …

A subset of patients with ulcerative colitis (UC) present with, or progress to, moderate to
severe disease activity. These patients are at high risk for colectomy, hospitalization …

Colorectal cancer (CRC), a multifactorial disease, is usually induced and developed through
complex mechanisms, including impact of diet and lifestyle, genomic abnormalities, change …

Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as
key factors governing tumor growth, metastasis, and response to therapies including …

Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than
women. This study aims to explain the potential causes of such sexual dimorphism in CRC …