[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels
AM Natale, PE Deal, DL Minor Jr - Journal of molecular biology, 2021 - Elsevier
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
Mechanism of adipose-derived mesenchymal stem cell-derived extracellular vesicles carrying miR-21-5p in hyperoxia-induced lung injury
Y Wu, Z Zhang, J Li, H Zhong, R Yuan, Z Deng… - Stem Cell Reviews and …, 2022 - Springer
Hyperoxia-induced lung injury (HILI) tends to develop bronchopulmonary dysplasia.
Adipose-derived mesenchymal stem cell (ADMSC)-derived extracellular vesicles (EVs) hold …
Adipose-derived mesenchymal stem cell (ADMSC)-derived extracellular vesicles (EVs) hold …
Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias
C Wang, L Zhou, C Liu, J Qiao, X Han, L Wang… - Nature …, 2024 - nature.com
Autonomic nervous system disorders play a pivotal role in the pathophysiology of
cardiovascular diseases. Regulating it is essential for preventing and treating acute …
cardiovascular diseases. Regulating it is essential for preventing and treating acute …
Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway
B Guo, Z Zuo, X Di, Y Huang, G Gong, B Xu… - Cell Communication and …, 2022 - Springer
Abstract Background and Purpose Hyperoxia-induced acute lung injury (HALI) is a critical
life-threatening disorder characterized by severe infiltration immune cells and death of type II …
life-threatening disorder characterized by severe infiltration immune cells and death of type II …
Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome
Q Jia, Y Yang, X Chen, S Yao, Z Hu - Respiratory Research, 2022 - Springer
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating
respiratory disorder with high rates of mortality and morbidity, but the detailed underlying …
respiratory disorder with high rates of mortality and morbidity, but the detailed underlying …
Mechanisms of impaired alveolar fluid clearance
H Taenaka, MA Matthay - The Anatomical Record, 2023 - Wiley Online Library
Impaired alveolar fluid clearance (AFC) is an important cause of alveolar edema fluid
accumulation in patients with acute respiratory distress syndrome (ARDS). Alveolar edema …
accumulation in patients with acute respiratory distress syndrome (ARDS). Alveolar edema …
[HTML][HTML] Function of KvLQT1 potassium channels in a mouse model of bleomycin-induced acute lung injury
M Aubin Vega, A Girault, É Meunier, J Chebli… - Frontiers in …, 2024 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is characterized by an exacerbated
inflammatory response, severe damage to the alveolar-capillary barrier and a secondary …
inflammatory response, severe damage to the alveolar-capillary barrier and a secondary …
Evaluation of interleukin‐1 and interleukin‐6 receptor antagonists in a murine model of acute lung injury
É Meunier, M Aubin vega, D Adam… - Experimental …, 2024 - Wiley Online Library
The acute exudative phase of acute respiratory distress syndrome (ARDS), a severe form of
respiratory failure, is characterized by alveolar damage, pulmonary oedema, and an …
respiratory failure, is characterized by alveolar damage, pulmonary oedema, and an …
Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury
T Zyrianova, B Lopez, K Zou, C Gu… - … of Physiology-Lung …, 2023 - journals.physiology.org
Influenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in
300,000–650,000 deaths. Preventive vaccination programs and antiviral medications …
300,000–650,000 deaths. Preventive vaccination programs and antiviral medications …
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation
CB Schroeter, C Nelke, M Schewe, L Spohler… - Biological …, 2023 - degruyter.com
Modulation of two-pore domain potassium (K2P) channels has emerged as a novel field of
therapeutic strategies as they may regulate immune cell activation and metabolism …
therapeutic strategies as they may regulate immune cell activation and metabolism …