Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

This review describes the enzymes responsible for the post‐translational modifications of
tubulin, including detyrosination/tyrosination, acetylation/deacetylation, phosphorylation …

Following the initial demonstration of phosphorylation of endogenous brain proteins
(Johnson et al., 1971), two decades of work have shown that this biochemical mechanism …

Extant proteins exploit thermodynamically activated negatively charged coenzymes and
hydrotropes to temporally access mechanistically important conformations that regulate vital …

The G protein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase that
phosphorylates and desensitizes agonist-occupied G protein-coupled receptors (GPCRs) …

Microtubules, with intermediate filaments and microfilaments, are the components of the cell
skeleton which determinates the shape of a cell. Microtubules are involved in different …

Alzheimer disease (AD) is a clinicopathologic syndrome of unknown etiology with numerous
abnormalities in neuronal and nonneuronal cells. A review of the literature suggests that a …

Although the β-adrenergic receptor kinase (βARK) mediates agonist-dependent
phosphorylation and desensitization of G protein-coupled receptors, recent studies suggest …

Purified brain tubulin subjected to an exhaustive phosphatase treatment can be
rephosphorylated by casein kinase II. This phosphorylation takes place mainly on a serine …

The cellular cytoskeleton, consisting of actin filaments, microtubules and intermediate
filaments, is involved in fundamental processes such as cell division, cell migration, shape …