Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Tumor progression involves invasion, migration, metabolism, autophagy, exosome
secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie …

Microglia-mediated neuroinflammatory response, one of the most essential pathological
processes of cerebral ischemia-reperfusion (I/R) injury, is acknowledged as the main factors …

The Golgi apparatus is at the center of protein processing and trafficking in normal cells.
Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor …

Tumors are equipped with a highly complex machinery of interrelated events so as to adapt
to hazardous conditions, preserve a growing cell mass and thrive at the site of metastasis …

Currently, breast carcinoma is the most common form of malignancy and the main cause of
cancer mortality in women worldwide. The metastasis of cancer cells from the primary tumor …