Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

An overview of pre‐ribosomal RNA processing in eukaryotes

AK Henras, C Plisson‐Chastang… - Wiley …, 2015 - Wiley Online Library
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

KE Bohnsack, MT Bohnsack - The EMBO journal, 2019 - embopress.org
The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA

NJ Watkins, MT Bohnsack - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Abstract Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found
throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea [snoRNP‐like …

Eukaryotic ribosome biogenesis at a glance

E Thomson, S Ferreira-Cerca… - Journal of cell …, 2013 - journals.biologists.com
Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

[HTML][HTML] Driving ribosome assembly

D Kressler, E Hurt, J Baβler - … et Biophysica Acta (BBA)-Molecular Cell …, 2010 - Elsevier
Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

A puzzle of life: crafting ribosomal subunits

D Kressler, E Hurt, J Baßler - Trends in biochemical sciences, 2017 - cell.com
The biogenesis of eukaryotic ribosomes is a complicated process during which the
transcription, modification, folding, and processing of the rRNA is coupled with the ordered …

[HTML][HTML] The exosome is recruited to RNA substrates through specific adaptor proteins

M Thoms, E Thomson, J Baßler, M Gnädig, S Griesel… - Cell, 2015 - cell.com
The exosome regulates the processing, degradation, and surveillance of a plethora of RNA
species. However, little is known about how the exosome recognizes and is recruited to its …

RNA helicase proteins as chaperones and remodelers

I Jarmoskaite, R Russell - Annual review of biochemistry, 2014 - annualreviews.org
Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …

[HTML][HTML] A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits

BS Strunk, MN Novak, CL Young, K Karbstein - Cell, 2012 - cell.com
Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal
subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs …