Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central
nervous system (CNS) during the early stages of embryonic development. After colonizing …

Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …