Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …

Chromatin is organized into topologically associating domains (TADs) enriched in distinct
histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung
cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase …

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and
is associated with decreased or absent expression of the transcription factor NK2 homeobox …

The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular
physiology that tightly regulates cellular protein concentrations with specificity and precision …

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-
box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase …

Uncontrolled activation of tumor necrosis factor receptor–associated factor (TRAF) proteins
may result in profound tissue injury by linking surface signals to cytokine release. Here we …