The new normal: immunomodulatory agents against sepsis immune suppression
NA Hutchins, J Unsinger, RS Hotchkiss… - Trends in molecular …, 2014 - cell.com
Sepsis is the leading cause of death among critically ill patients in intensive care units, and
treatment options are limited. Therapies developed against the proinflammatory stage have …
treatment options are limited. Therapies developed against the proinflammatory stage have …
[HTML][HTML] Anti-viral CD8 T cells and the cytokines that they love
MA Cox, SM Kahan, AJ Zajac - Virology, 2013 - Elsevier
Viral infections cause an immunological disequilibrium that provokes CD8 T cell responses.
These cells play critical roles in purging acute infections, limiting persistent infections, and …
These cells play critical roles in purging acute infections, limiting persistent infections, and …
A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
Animal models for HIV cure research
BB Policicchio, I Pandrea, C Apetrei - Frontiers in immunology, 2016 - frontiersin.org
The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
Engineering CAR T cells to target the HIV reservoir
W Mu, MA Carrillo, SG Kitchen - Frontiers in cellular and infection …, 2020 - frontiersin.org
The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a
therapeutic cure for HIV. Several strategies have been developed to purge the reservoir …
therapeutic cure for HIV. Several strategies have been developed to purge the reservoir …
IL-7 in SARS-CoV-2 infection and as a potential vaccine adjuvant
Y Bekele, Y Sui, JA Berzofsky - Frontiers in Immunology, 2021 - frontiersin.org
IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of
many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in …
many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in …
Cytokine-mediated regulation of CD8 T-cell responses during acute and chronic viral infection
The common γ-chain cytokines, interleukin (IL)-2, IL-7, and IL-15, regulate critical aspects of
antiviral CD8 T-cell responses. During acute infections, IL-2 controls expansion and …
antiviral CD8 T-cell responses. During acute infections, IL-2 controls expansion and …
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4+ T cell
depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 …
depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 …
Non-human primates in HIV research: Achievements, limits and alternatives
An ideal model for HIV-1 research is still unavailable. However, infection of non-human
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
Recent advances in poor HIV immune reconstitution: what will the future look like?
W Zhang, L Ruan - Frontiers in Microbiology, 2023 - frontiersin.org
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing
viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected …
viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected …