NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ)
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …

Background Neuroinflammation‐induced secondary injury is an important cause of
sustained progression of spinal cord injury. Inflammatory programmed cell death pyroptosis …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Background Currently, spinal cord injury (SCI) is a pathological incident that triggers several
neuropathological conditions, leading to the initiation of neuronal damage with several pro …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Neuroinflammation plays a crucial role in the secondary phase of spinal cord injury (SCI),
and is initiated following the activation of toll-like receptor 4 (TLR4). However, the …

Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to
neuropathological conditions which have in consequence the initiation of pro‐inflammatory …