Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

Bisphenol A (BPA) is ubiquitous in humans and the environment. Its potential adverse
effects through genomic and non-genomic pathways have fostered BPA replacement by …

Piperidine is an important pharmacophore, a privileged scaffold and an excellent
heterocyclic system in the field of drug discovery which provides numerous opportunities in …

The residues of bisphenol A (BPA) in milk packaging may transfer to milk, adversely
affecting the human endocrine system. Consequently, to analyse or monitor BPA, it is …

Background Cancer is at present one of the leading causes of death in the world. It accounts
for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of …

Background: Bisphenol-A (BPA) is widely used and ubiquitous in the environment. Animal
studies indicate that BPA affects reproduction, however, the gene-environment interaction …

Estrogen receptors (ERs) are a group of compounds named for their importance in both
menstrual and estrous reproductive cycles. They are involved in the regulation of various …

Bisguaiacols are promising lignin-derivable alternatives to bisphenol A (BPA), but limited
bioassay data are available on their estrogenic activity (EA). Herein, we investigated the …

Selective estrogen receptor downregulators (SERDs) are a novel class of compounds
capable of reducing the ERα protein level and blocking ER activity. Therefore, SERDs are …