Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …

Relapsed rhabdomyosarcoma (RMS) represents a significant therapeutic challenge. Nearly
one-third of patients diagnosed with localized RMS and over two-thirds of patients with …

Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …

Children with rare, relapsed or refractory cancers often face limited treatment options, and
few predictive biomarkers are available that can enable personalized treatment …

Bladder cancer is one of the most frequently occurring malignant tumors in the urinary
system. Sodium butyrate (NaB) is a histone deacetylase inhibitor and exerts remarkable …

Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult
to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue …

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing
lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood …

Rhabdomyosarcoma, the most common soft tissue sarcoma noted in childhood, requires
multimodality treatment, including chemotherapy, surgical resection, and/or radiation …

Simple Summary In this review, the history of RNA interference discovery and current
knowledge about microRNA biogenesis and post-transcriptional regulation of gene …

While sarcomas account for approximately 1% of malignant tumors of adults, they are
particularly more common in children and adolescents affected by cancer. In contrast to …