The physiological functions of human peroxisomes
RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
Cellular functions and molecular mechanisms of non-lysine ubiquitination
AJ McClellan, SH Laugesen, L Ellgaard - Open Biology, 2019 - royalsocietypublishing.org
Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
[HTML][HTML] PEX5 translocation into and out of peroxisomes drives matrix protein import
ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Protein import into peroxisomes occurs through a nuclear pore–like phase
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
[HTML][HTML] Emerging role of ubiquitination in the regulation of PD-1/PD-L1 in cancer immunotherapy
X Hu, J Wang, M Chu, Y Liu, Z Wang, X Zhu - Molecular Therapy, 2021 - cell.com
A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …
[HTML][HTML] Non-lysine ubiquitylation: Doing things differently
IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
[HTML][HTML] La FAM fatale: USP9X in development and disease
Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-
post-translational modifiers function as the final arbitrators of a protein substrate's …
post-translational modifiers function as the final arbitrators of a protein substrate's …
[HTML][HTML] Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders
Y Fujiki, K Okumoto, M Honsho, Y Abe - Biochimica et Biophysica Acta …, 2022 - Elsevier
Peroxisomes are single-membrane organelles essential for cell metabolism including the β-
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …
[HTML][HTML] Pexophagy: a model for selective autophagy
K Germain, PK Kim - International journal of molecular sciences, 2020 - mdpi.com
The removal of damaged or superfluous organelles from the cytosol by selective autophagy
is required to maintain organelle function, quality control and overall cellular homeostasis …
is required to maintain organelle function, quality control and overall cellular homeostasis …
[HTML][HTML] Multiple pathways for protein transport to peroxisomes
PK Kim, EH Hettema - Journal of molecular biology, 2015 - Elsevier
Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …