Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of
pharmacotherapeutic interventions in a variety of indications, with currently more than 40 …

A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Abstract Antigen targeting,,,, and adjuvancy schemes, that respectively facilitate delivery of
antigen to dendritic cells and elicit their activation have been explored in vaccine …

Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can
mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano …

The convenience of subcutaneous (SC) administration and the increasing interest in
monoclonal antibody (mAb)-based therapies for chronic diseases, hint their potential for SC …

Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of
tissues. To investigate these roles and exploit them for tissue engineering or to overcome …

The subcutaneous (SC) route is of growing interest for the administration of biotherapeutics.
Key products on the biotherapeutic market such as insulins, but also several …

Therapeutic delivery selectively to lymph nodes has the potential to address a variety of
unmet clinical needs. However, owing to the unique structure of the lymphatics and the size …

Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on
the basis of the physicochemical and mechanical characteristics of nanoparticles. Research …