[HTML][HTML] Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

[PDF][PDF] After a century of nisin research-where are we now?

D Field, M Fernandez de Ullivarri… - FEMS microbiology …, 2023 - academic.oup.com
It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in
the same year that penicillin was first described. Over the last 100 years this small, highly …

Considerations and caveats in combating ESKAPE pathogens against nosocomial infections

YX Ma, CY Wang, YY Li, J Li, QQ Wan… - Advanced …, 2020 - Wiley Online Library
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

[HTML][HTML] Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus

J Kaur, X Cao, NS Abutaleb, A Elkashif… - Journal of medicinal …, 2020 - ACS Publications
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired
infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance …

Development and therapeutic potential of selenazo compounds

AC Ruberte, C Sanmartin, C Aydillo… - Journal of Medicinal …, 2019 - ACS Publications
Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

[HTML][HTML] Thioredoxin reductase is a valid target for antimicrobial therapeutic development against gram-positive bacteria

LO Felix, E Mylonakis, BB Fuchs - Frontiers in Microbiology, 2021 - frontiersin.org
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …

Evaluation of 1, 3, 4-thiadiazole carbonic anhydrase inhibitors for gut decolonization of vancomycin-resistant enterococci

NS Abutaleb, A Shrinidhi, AB Bandara… - ACS Medicinal …, 2023 - ACS Publications
Vancomycin-resistant enterococci (VRE), Enterococcus faecium and Enterococcus faecalis,
are high-priority drug-resistant pathogens in need of new therapeutic approaches. VRE …

In Vivo Antibacterial Activity of Acetazolamide

NS Abutaleb, A Elkashif, DP Flaherty… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Vancomycin-resistant enterococci (VRE) represent a major public health threat that requires
the development of new therapeutics. In the present study, acetazolamide (AZM) was …

Ebselen optimized the therapeutic effects of silver nanoparticles for periodontal treatment

Y Liang, B Wang, Q Yu, W Wang, S Ge… - International Journal of …, 2023 - Taylor & Francis
Objective Silver nanoparticles (AgNPs) possess excellent antibacterial effects on
periodontal pathogens, but their clinical application is limited mainly due to their cytotoxicity …