Antibody-mediated encephalitis

J Dalmau, F Graus - New England Journal of Medicine, 2018 - Mass Medical Soc
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes
disorders with relatively distinct characteristics such as psychosis, seizures, abnormal …

Adolescence as a neurobiological critical period for the development of higher-order cognition

B Larsen, B Luna - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …

The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Glutamatergic dysfunction in Schizophrenia

AO Kruse, JR Bustillo - Translational Psychiatry, 2022 - nature.com
The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

J Kindler, CK Lim, CS Weickert, D Boerrigter… - Molecular …, 2020 - nature.com
The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system
activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is …

PSD95: A synaptic protein implicated in schizophrenia or autism?

AA Coley, WJ Gao - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

The NMDA receptor and schizophrenia: from pathophysiology to treatment

DT Balu - Advances in pharmacology, 2016 - Elsevier
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

Brain NMDA receptors in schizophrenia and depression

A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex

M Wang, Y Yang, CJ Wang, NJ Gamo, LE Jin… - Neuron, 2013 - cell.com
Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …