Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or
decorated with biologically active targeting ligands. These targeting ligands can be …

Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is
particularly adept at screening small molecule (SM) targets without requiring any structural …

Nanobodies (NB) are powerful tools for biotechnological and therapeutic applications. They
strongly bind to their targets and are very stable. Early studies showed that NB unfolding is …

Members of the SH3-and ankyrin repeat (SHANK) protein family are considered as master
scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations …

A complete understanding of protein function and dynamics requires the characterization of
the multiple thermodynamic states, including the denatured state ensemble (DSE). Whereas …

Changes in protein stability due to side-chain mutations are evaluated by alchemical free-
energy calculations based on classical molecular dynamics (MD) simulations in explicit …

Intrinsic disorder plays an important functional role in proteins. Disordered regions are
linked to posttranslational modifications, conformational switching, extra/intracellular …

Despite the generally accepted role of the hydrophobic effect as the driving force for folding,
many intrinsically disordered proteins (IDPs), including those with hydrophobic content …

The public health threat from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) continues to intensify with emerging variants of concern (VOC) aiming to render COVID …

We report a method of enzyme stabilisation exploiting the artificial protein chaperone
properties of β-cyclodextrin (β-CD) covalently embedded in an ultrathin organosilica layer …