Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

Objective To relate in-hospital mortality to early transfusion of plasma and/or platelets and to
time-varying plasma: red blood cell (RBC) and platelet: RBC ratios. Design Prospective …

Objective: Injury and shock lead to alterations in conventional coagulation tests (CCTs).
Recently, rapid thrombelastography (r-TEG) has become recognized as a comprehensive …

Background The endothelial glycocalyx layer (EGL) is a key regulator of vascular
permeability, cell adhesion, and inflammation. The EGL is primarily composed of syndecan …

BACKGROUND: The use of plasma-based resuscitation for trauma patients in hemorrhagic
shock has been associated with a decrease in mortality. Although some have proposed a …

Objective: Investigate and confirm the association between sympathoadrenal activation,
endotheliopathy and poor outcome in trauma patients. Background: The association …

The glycocalyx is a carbohydrate-rich layer that lines the luminal side of the vascular
endothelium. Its soluble components exist in a dynamic equilibrium with the bloodstream …

Abstract Background. The current West Africa Ebola virus disease (EVD) outbreak has
resulted in multiple individuals being medically evacuated to other countries for clinical …

We have recently demonstrated that injured patients in hemorrhagic shock shed syndecan 1
and that the early use of fresh frozen plasma (FFP) in these patients is correlated with …