Embracing complexity in sepsis
AR Schuurman, PMA Sloot, WJ Wiersinga… - Critical Care, 2023 - Springer
Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of
organ systems, medical interventions and a myriad of other factors. This together results in a …
organ systems, medical interventions and a myriad of other factors. This together results in a …
Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …
[HTML][HTML] An activity-guided map of electrophile-cysteine interactions in primary human T cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …
on immune cells. These compounds are thought to act by cysteine modification to alter the …
PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma
Y Liu, L Ouyang, C Mao, Y Chen, T Li, N Liu, Z Wang… - Oncogene, 2022 - nature.com
Liver cancer, a result of multifactorial interplay between heredity and the environment, is one
of the leading causes of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is …
of the leading causes of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is …
Cis interactions between CD2 and its ligands on T cells are required for T cell activation
CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas,
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …
[HTML][HTML] Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation
Aging is associated with DNA accumulation and increased homeostatic proliferation of
circulating T cells. Although these attributes are associated with aging-related autoimmunity …
circulating T cells. Although these attributes are associated with aging-related autoimmunity …
NLRC4 promotes the cGAS‐STING signaling pathway by facilitating CBL‐mediated K63‐linked polyubiquitination of TBK1
R Zhang, W Yang, H Zhu, J Zhai… - Journal of medical …, 2023 - Wiley Online Library
Abstract TANK‐binding kinase 1 (TBK1) is crucial in producing type Ⅰ interferons (IFN‐Ⅰ)
that play critical functions in antiviral innate immunity. The tight regulation of TBK1 …
that play critical functions in antiviral innate immunity. The tight regulation of TBK1 …
Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination
G Voisinne, M Locard-Paulet, C Froment, E Maturin… - Nature …, 2022 - nature.com
T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens.
According to the kinetic proofreading model, antigen discrimination properties could be …
According to the kinetic proofreading model, antigen discrimination properties could be …
PLCγ1 promotes phase separation of T cell signaling components
The T cell receptor (TCR) pathway receives, processes, and amplifies the signal from
pathogenic antigens to the activation of T cells. Although major components in this pathway …
pathogenic antigens to the activation of T cells. Although major components in this pathway …